Research Purpose / Projects

01Development of Pluripotent Stem Cells, Including Development of Next-generation iPS Cells

Establish a system to produce next-generation iPS cells (iPS cell 2.0*) for clinical applications

*iPS cells with high establishment and differentiation efficiencies and low variability
  • Develop improved ES cells directly derived from the naïve epiblasts of human embryos
  • Establish methods to generate iPS cells with low immunogenicity
  • Evaluate the differentiation potentials of iPS cell 2.0 and improved ES cells

02Development of Innovative Highly Functional Cells

  • Develop basic technologies to produce “designer cells” with functional enhancements suitable for transplantation by focusing on technological advances in DNA, RNA, and protein engineering
  • Develop highly functional cells to improve the production efficiency of gene therapeutic vectors

03Research to Elucidate the Mechanisms of Reprogramming, Development, and Regeneration

  • Provide feedback for establishing iPS cell 2.0 through detailed analysis of reprogramming factors
  • Use human embryos and blastoids to elucidate mechanisms of reprogramming and development
  • Enhance the functional maturation of different cell types for transplantation using models that mimic developmental processes

04Development of Next-generation Genome Editing and Gene Delivery Technologies

  • Develop next-generation genome editing technology platform for industrialization
  • Develop advanced gene delivery technology using RNA, virus-like particles, cells, etc.
  • Establish tissue-specific gene delivery technology

05Development of Technologies to Integrate Cell and Gene Therapies

  • Establish technology to create designer cells (highly functional cells)
  • Develop in vivo gene transfer methods to optimize the host environment
  • Establish ex vivo in utero therapies for rare pediatric diseases
  • Create a platform for in vivo reprogramming

06Fundamental Research to Promote the Application of Cell and Gene Therapies

  • Promote automation and digital transformation of iPS cell production and quality control
  • Develop automated, all-in-one culture systems for iPSC products
  • Develop novel animal models for pre-clinical studies of next-generation regenerative medical products
  • Develop cell characterization based on multi-layered genome information analysis

07Functioning as a Central Hub

Bring together researchers across disciplines, borders, and industries to participate to build a platform for the development of next-generation cell and gene therapies.

08Fostering Young Researchers

  • To foster young researchers who will lead the next generation with advanced specialization and multi-skills

Last updated: March 21, 2024